To utter a long loud piercing cry, as from pain or fear. To make a loud piercing sound: Jet planes screamed through the air. To speak or write in a heated hysterical manner. To have or produce a startling effect: The outlandish costume screamed with clashing colors. To utter or say in or as if in a screaming voice. A long, loud, piercing cry or sound. Informal One that is hilariously or ridiculously funny: The new play was a scream.