To refuse to accept, submit to, believe, or make use of. To refuse to consider or grant; deny. To refuse to recognize or give affection to (a person). To discard as defective or useless; throw away. See Synonyms at refuse1. To spit out or vomit. Medicine To resist immunologically the introduction of (a transplanted organ or tissue); fail to accept as part of one's own body. One that has been rejected: a reject from the varsity team; a tire that is a reject.