Biology To replace (a lost or damaged organ or part) by the formation of new tissue. To form, construct, or create anew: Any part of the hologram can be used to regenerate the whole image. To give new life or energy to; revitalize: a new book to regenerate the flagging interest of his readers. To reform spiritually or morally:"The sacraments come from God and regenerate the person"(Radclyffe Hall). To effect regeneration: Can the damaged nerves regenerate? To become formed or constructed again. To undergo spiritual conversion or rebirth; reform. Spiritually or morally reformed. Formed by regeneration: regenerate tissue.