To put or throw flat with the face down, as in submission or adoration: "He did not simply sit and meditate, he also knelt down, sometimes even prostrated himself\u201d ( Iris Murdoch). To cause to lie flat: The wind prostrated the young trees. To reduce to extreme weakness or incapacitation; overcome: an illness that prostrated an entire family; a nation that was prostrated by years of civil war. Lying face down, as in submission or adoration. Lying flat or at full length. Reduced to extreme weakness or incapacitation; overcome. Botany Growing flat along the ground.