What is origin? What is origin? Anatomy The point of attachment of a muscle that remains relatively fixed during contraction.Mathematics The point of intersection of coordinate axes, as in the Cartesian coordinate system.The point at which something comes into existence or from which it derives or is derived.Ancestry: "We cannot escape our origins, however hard we try” ( James Baldwin). The fact of originating; rise or derivation: The rumor had its origin in an impulsive remark.