nonspecific āļāļ·āļāļāļ°āđāļĢ nonspecific āļāļ·āļāļāļ°āđāļĢ Of or relating to an infection not known to be caused by a specific pathogen: nonspecific urethritis. Of or relating to immunity that occurs naturally as a result of a person's genetic makeup or physiology and does not arise from a previous infection or vaccination.