Cos'è manual? Cos'è manual? Of or relating to the hands: manual skill. Done by, used by, or operated with the hands.Employing human rather than mechanical energy: manual labor. Of, relating to, or resembling a small reference book.A small reference book, especially one giving instructions.Music A keyboard, as of an organ or harpsichord, played with the hands.A machine operated by hand.Prescribed movements in the handling of a weapon, especially a rifle: the manual of arms.