Informal To complain naggingly or petulantly; grumble. To have sharp pains in the bowels. Informal To irritate; annoy: Her petty complaints really gripe me. To cause sharp pain in the bowels of. To grasp; seize. To oppress or afflict. Informal A complaint. Sharp, spasmodic pains in the bowels. A firm hold; a grasp. A grip; a handle.