An appeal or prayer for evil or misfortune to befall someone or something. The evil or misfortune that comes in or as if in response to such an appeal: bewailed the curse of ill health. One that is accursed. A source or cause of evil; a scourge: "Selfishness is the greatest curse of the human race\u201d ( William Ewart Gladstone). A profane word or phrase; a swearword. Ecclesiastical A censure, ban, or anathema. Slang Menstruation. Used with the. To invoke evil or misfortune upon; damn. To swear at. To bring evil upon; afflict: was cursed with crippling arthritis. Ecclesiastical To put under a ban or an anathema; excommunicate. To utter curses; swear.