To have charge of; manage. To give or apply in a formal way: administer the last rites. To apply as a remedy: administer a sedative. To direct the taking of (an oath). To mete out; dispense: administer justice. To manage or dispose of (a trust or estate) under a will or official appointment. To impose, offer, or tender (an oath, for example). To manage as an administrator. To minister: administering to their every whim.